Robust protein-based engineering of hepatocyte-like cells from human mesenchymal stem cells.
Tomoki TakashinaAkihiro MatsunagaYukiko ShimizuTetsushi SakumaTadashi OkamuraKunie MatsuokaTakashi YamamotoYukihito IshizakaPublished in: Hepatology communications (2023)
Taken together with observations that 4F-Heps were not tumorigenic in immunocompromised mice for at least 2 years, we propose that this artificial transcription system is a versatile tool for cell therapy for hepatic failures.