Altered Gene Expression along the Glycolysis-Cholesterol Synthesis Axis Is Associated with Outcome in Pancreatic Cancer.

Joanna M KarasinskaJames T TophamSteve E KallogerGun Ho JangRobert E DenrocheLuka CulibrkLaura M WilliamsonHui-Li WongMichael Kuan-Ching LeeGrainne M O'KaneRichard A MooreAndrew J MungallMalcolm J MooreCassia WarrenAndrew MetcalfeFaiyaz NottaJennifer J KnoxSteven GallingerJanessa LaskinMarco A Marra Steven J M JonesDaniel J RenoufDavid F Schaeffer

Published in: Clinical cancer research : an official journal of the American Association for Cancer Research (2019)

Metabolic classification specific to glycolytic and cholesterogenic pathways provides novel biological insight into previously established PDAC subtypes and may help develop personalized therapies targeting unique tumor metabolic profiles.See related commentary by Mehla and Singh, p. 6.

Keyphrases

gene expression
machine learning
dna methylation
deep learning
cancer therapy
drug delivery
drug induced