Human placental LRP5 and Sclerostin are increased in gestational diabetes mellitus pregnancies.
Anna PapadopoulouEirini ThymaraEirini MaratouGeorge KanellopoulosVasiliki PapaevangelouSophia KalantaridouSpyridon KanellakisPinelopi TriantafyllidouGeorge ValsamakisGeorge MastorakosPublished in: The Journal of clinical endocrinology and metabolism (2023)
Sclerostin and LRP5 were detected in human placentas. The overexpression of placental sclerostin and LRP5 values in GDM compared to non-GDM pregnancies, as well as the positive association of placental sclerostin values with pregestational maternal BMI and maternal fasting glucose concentrations may indicate the development of an adaptive mechanism in face of maternal hyperglycemia.
Keyphrases
- pregnancy outcomes
- endothelial cells
- birth weight
- gestational age
- pregnant women
- preterm birth
- induced pluripotent stem cells
- pluripotent stem cells
- blood glucose
- body mass index
- cell proliferation
- type diabetes
- transcription factor
- insulin resistance
- adipose tissue
- blood pressure
- low density lipoprotein
- skeletal muscle
- glycemic control