Loss of YAP1 C-terminus expression as an ancillary marker for metaplastic thymoma: a potential pitfall in detecting YAP1::MAML2 gene rearrangement.

Xuan WangLei-Lei LiuQing LiQiu-Yuan XiaRui LiSheng-Bing YeRu-Song ZhangRu FangHui ChenNan WuQiu Rao

Published in: Histopathology (2023)

YAP1 C-terminus immunohistochemistry is a highly sensitive and specific ancillary marker that distinguishes metaplastic thymoma from its mimics. BA-FISH assays could not effectively detect YAP1::MAML2 fusions due to the proximity of the two genes. Loss of YAP1 C-terminus expression is a reliable surrogate for the detection of YAP1::MAML2 fusions in metaplastic thymoma.

Keyphrases

poor prognosis
myasthenia gravis
gene expression
high throughput
transcription factor
high resolution
single molecule
label free
loop mediated isothermal amplification
sensitive detection
genome wide analysis
molecularly imprinted