ONO-7684 a novel oral FXIa inhibitor: Safety, tolerability, pharmacokinetics and pharmacodynamics in a first-in-human study.
Dominic BealeJeremy DennisonMalcolm BoyceFrancesca MazzoNaoki HondaPaul SmithMark BrucePublished in: British journal of clinical pharmacology (2021)
The data generated in this FIH study demonstrate the promising potential of oral FXIa inhibition and ONO-7684 for indications requiring anticoagulation.