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A Mixture of Polyunsaturated Fatty Acids ω-3 and ω-6 Reduces Melanoma Growth by Inhibiting Inflammatory Mediators in the Murine Tumor Microenvironment.

Ewin Barbosa AlmeidaKarina P H SilvaVitória da PaixãoJônatas do Bussador AmaralMarcelo RossiRoberta A Xavier-NavarroKarina V BarrosVera L F SilveiraRodolfo P VieiraLuis V F OliveiraElizabeth C PerezMiriam Galvonas JasiulionisAndré Luís Lacerda Bachi
Published in: International journal of molecular sciences (2019)
The oral administration of a 1:1 mixture of fish oil and soybean oil was able to alter the release of inflammatory mediators that are essential for a microenvironment favorable to the melanoma growth in mice, whereas fish oil or soybean oil alone was ineffective.
Keyphrases
  • fatty acid
  • oxidative stress
  • stem cells
  • signaling pathway
  • metabolic syndrome
  • skeletal muscle
  • insulin resistance
  • wild type