Maternal SARS-CoV-2 infection in pregnancy disrupts gene expression in Hofbauer cells with limited impact on cytotrophoblasts.

Elizabeth Ann L EnningaHuy Quang QuachJin Sung JangMaria Cristina Miranda de Araujo CorreiaYaroslav FedyshynBohdana FedyshynMaureen LemensDawn LittlefieldSupriya BehlElise Sintim-AboagyeMaria C Mejia PlazasMaria C CardenasShree ChakrabortySatoko YamaokaHideki EbiharaAkhilesh PandeyHu LiAndrew D BadleyErica L JohnsonJie SunAndrew P NorganRegan N TheilerHuy Quang Quach

Published in: PLoS pathogens (2024)

Our studies demonstrate a significant impact of indirect SARS-CoV-2 infection on gene expression of inner mesenchymal HBCs, with limited effect on lining CTB cells isolated from pregnant subjects infected and recovered from SARS-CoV-2. The pathways associated with these DEGs identify potential targets for therapeutic intervention.

Keyphrases

gene expression
induced apoptosis
sars cov
cell cycle arrest
respiratory syndrome coronavirus
dna methylation
randomized controlled trial
pregnant women
stem cells
pregnancy outcomes
bone marrow
signaling pathway
risk assessment
oxidative stress
preterm birth
human health
coronavirus disease
birth weight