In vitro effect of biological and conventional disease-modifying antirheumatic drugs on fibrocyte differentiation in patients with rheumatoid arthritis and healthy controls.
Helene Broch TenstadPernille Just VinholtChristian NielsenHanne M LindegaardSøren Andreas JustPublished in: European journal of rheumatology (2021)
Abatacept and prednisolone suppress the differentiation of mononuclear cells to mature fibrocytes in vitro in patients with RA, and data indicate a similar effect of tocilizumab; this was further supported by the observed dose-response relationship. Clinical trials are needed to compare the effect of these drugs on fibrotic RA manifestations, for example, RA-ILD.
Keyphrases
- rheumatoid arthritis
- interstitial lung disease
- disease activity
- clinical trial
- rheumatoid arthritis patients
- induced apoptosis
- ankylosing spondylitis
- systemic sclerosis
- cell cycle arrest
- electronic health record
- idiopathic pulmonary fibrosis
- peripheral blood
- systemic lupus erythematosus
- big data
- drug induced
- artificial intelligence
- signaling pathway
- pi k akt