Finerenone Dose-Exposure-Serum Potassium Response Analysis of FIDELIO-DKD Phase III: The Role of Dosing, Titration, and Inclusion Criteria.

Sebastiaan Camiel GouloozeNelleke SnelderAndreas SeelmannAndrea Horvat-BroeckerMeike BrinkerAmer JosephDirk GarmannJoerg LippertThomas Eissing

Published in: Clinical pharmacokinetics (2021)

The analyses demonstrated the effectiveness of finerenone dose titration in managing serum potassium and provide a quantitative basis to guide safe clinical use.

Keyphrases

phase iii
open label
clinical trial
randomized controlled trial
systematic review
double blind
phase ii
placebo controlled
study protocol