HLA-A*23 Is Associated With Lower Odds of Acute Retroviral Syndrome in Human Immunodeficiency Virus Type 1 Infection: A Multicenter Sub-Saharan African Study.
Lovisa LindquistWilliam KilembeEtienne KaritaMatt A PriceAnatoli KamaliPontiano KaleebuJianming TangSusan AllenEric HunterJill GilmourSarah L Rowland-JonesEduard J SandersAmin S HassanJoakim EsbjörnssonPublished in: Open forum infectious diseases (2024)
The role of human leukocyte antigen (HLA) class I and killer immunoglobulin-like receptor molecules in mediating acute retroviral syndrome (ARS) during human immunodeficiency virus type 1 (HIV-1) infection is unclear. Among 72 sub-Saharan African adults, HLA-A*23 was associated with lower odds of ARS (adjusted odds ratio, 0.10 [95% confidence interval, .01-.48]; P = .009), which warrants further studies to explore its role on HIV-1-specific immunopathogenesis.
Keyphrases
- human immunodeficiency virus
- antiretroviral therapy
- hiv infected
- liver failure
- hepatitis c virus
- hiv positive
- hiv aids
- respiratory failure
- aortic dissection
- endothelial cells
- drug induced
- case report
- hepatitis b virus
- cross sectional
- hiv testing
- south africa
- men who have sex with men
- binding protein
- intensive care unit