KIO 3 -catalyzed selective oxidation of thiols to disulfides in water under ambient conditions.
José R L SousaMarcelo Straesser FrancoLeila D MendesLucas A AraújoJose S S NetoTiago E A FrizonVanessa B Dos SantosEduardo Carasek da RochaSumbal SabaJamal RafiqueAntonio Luiz BragaPublished in: Organic & biomolecular chemistry (2024)
Herein, we report a KIO 3 -catalyzed oxidative coupling of thiols to their corresponding disulfides in water, in a short time and at ambient temperature. The reaction has a broad scope and exhibits good functional group tolerance, resulting in the desired products in excellent yields. This approach allows the reuse of the reaction system in multiple cycles and scale-up. Furthermore, the current protocol demonstrates compatibility for in situ generation of disulfides and post application in C(sp 2 )-H bond sulfenylation.