A genome-wide association study meta-analysis in a European sample of stage III/IV grade C periodontitis patients ≤35 years of age identifies new risk loci.
Silvia Diz De AlmeidaGesa M RichterAlicia de CooSøren JepsenInes Kapferer-SeebacherHenrik DommischKlaus BergerMatthias LaudesWolfgang LiebBruno G LoosNathalie van der VeldeNatasja van SchoorLisette de Grootnull nullJuan Blanco-CarriónAngel CarracedoRaquel CruzArne S SchaeferPublished in: Journal of clinical periodontology (2023)
This study expands the set of known genetic loci for severe periodontitis with an age of onset ≤35 years. The putative functions ascribed to the associated genes highlight the significance of oral barrier tissue stability, wound healing and tissue regeneration in the aetiology of these periodontitis forms and suggest the importance of tissue regeneration in maintaining oral health.
Keyphrases
- genome wide association study
- genome wide
- wound healing
- systematic review
- stem cells
- end stage renal disease
- oral health
- dna methylation
- ejection fraction
- chronic kidney disease
- newly diagnosed
- copy number
- peritoneal dialysis
- randomized controlled trial
- early onset
- gene expression
- meta analyses
- genome wide association
- patient reported outcomes
- patient reported
- bioinformatics analysis