FAP expression in alpha cells of Langherhans insulae-implications for FAPI radiopharmaceuticals' use.

Margarita Kirienko Giovanni CentonzeGiovanna SabellaMauro Sollai Martina Sollini Xiaoli LanHaojun ChenLuigi M Terracciano Ettore Seregni Massimo Milione

Published in: European journal of nuclear medicine and molecular imaging (2023)

Pancreatic Langerhans islet alpha cells normally express FAP. This is not expected to influence the diagnostic accuracy of FAP-targeting tracers. In the therapeutic setting, our results suggest the need to better elucidate FAPI radioligands' effects on the Langerhans insulae function.

Keyphrases

induced apoptosis
cell cycle arrest
poor prognosis
cell death
drug delivery
cell proliferation