Does advanced paternal age affect global DNA methylation of human spermatozoa and intracytoplasmic sperm injection outcome?

Published in: Journal of the Turkish German Gynecological Association (2022)

These results suggest that advanced paternal age increased the DNA fragmentation, chromatin decondensation, and global DNA methylation level in human spermatozoa, which negatively affects the ICSI outcomes in couples undergoing ICSI cycles.

Keyphrases

dna methylation
endothelial cells
genome wide
gene expression
induced pluripotent stem cells
pluripotent stem cells
transcription factor
pregnant women
adipose tissue
cell free
circulating tumor
copy number
ultrasound guided