Transcription dosage compensation does not occur in Down syndrome.

Samuel HunterRobin D DowellJosephina HendrixJustin FreemanMary Ann Allen

Published in: bioRxiv : the preprint server for biology (2023)

Transcriptional dosage compensation does not occur in Down syndrome. Simulated data containing no dosage compensation can appear to have dosage compensation when analyzed via standard methods. Moreover, some chromosome 21 genes that appear to be dosage compensated are consistent with allele specific expression.

Keyphrases

transcription factor
poor prognosis
gene expression
machine learning
copy number