Thyroid transcription factor-1 expression in lung neuroendocrine tumours: a gender-related biomarker?
Anna La SalviaAlessandra SicilianiMaria RinzivilloMonica VerricoRoberto BaldelliGiulia PulianiRoberta ModicaIsabella ZanataIrene PersanoGiuseppe FanciulliMassimiliano BassiMassimiliano ManciniStefania BellinoElisa GiannettaMohsen IbrahimFrancesco PanzutoMaria Pia BrizziAntongiulio FaggianoPublished in: Endocrine (2023)
This study highlights that TTF-1 positivity differs according to sex in lung NET, with a more common TTF-1 positive staining in female. Moreover, TTF-1 positivity correlated with the absence of necrosis. These data suggest that TTF-1 could potentially represent a gender-related biomarker for lung NET.