All-trans retinoic acid induces leukemia resistance to NK cell cytotoxicity by down-regulating B7-H6 expression via c-Myc signaling.

Guoshuai CaoYing ChengXiaodong ZhengHaiming WeiZhigang TianRui SunHaoyu Sun

Published in: Cancer communications (London, England) (2021)

atRA treatment promotes tumor cell resistance against NK cell-mediated lysis by down-regulating B7-H6 expression via the c-Myc signaling pathway, suggesting that more attention needs to be paid to the immunological adverse effects in the clinical use of atRA treatment.

Keyphrases

nk cells
poor prognosis
signaling pathway
single cell
stem cells
working memory
combination therapy
binding protein
long non coding rna
epithelial mesenchymal transition
pi k akt
oxidative stress
smoking cessation