Bone marrow microenvironments that contribute to patient outcomes in newly diagnosed multiple myeloma: A cohort study of patients in the Total Therapy clinical trials.
Samuel A DanzigerMark McConnellJake GockleyMary H YoungAdam RosenthalFrank SchmitzDavid J ReissPhillip FarmerDaisy V AlapatAmrit P SinghCody AshbyMichael A BauerYan RenKelsie SmithSuzana S CoutoFrits van RheeFaith DaviesMaurizio ZangariNathan PettyRobert Z OrlowskiMadhav V DhodapkarWilbert B CopelandBrian FoxAntje HoeringAlison FitchKatie NewhallBart BarlogieMatthew W B TrotterRobert M HershbergBrian A WalkerAndrew P DervanAlexander V RatushnyGareth J MorganPublished in: PLoS medicine (2020)
In this study, we observe that granulocyte signatures in the MM TME contribute to a more accurate prognosis. This implies that future researchers and clinicians treating patients should quantify TME components, in particular monocytes and granulocytes, which are often ignored in microenvironment studies.