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Quantitative magnetic resonance neurographic characterization of peripheral nerve involvement in manifest and pre-ataxic spinocerebellar ataxia type 3.

Jennifer C HayesMarkus WeilerGeorges SamJennifer FaberJohn M HayesSabine HeilandMartin BendszusWolfgang WickHeike Jacobi
Published in: European journal of neurology (2022)
Our data provide a comprehensive characterization of peripheral nerve damage in SCA3 and assist in understanding the mechanisms of the multisystemic disease evolution. Evidence of peripheral nerve involvement prior to the onset of clinically overt ataxia might have important implications for designing early intervention studies.
Keyphrases
  • peripheral nerve
  • magnetic resonance
  • early onset
  • randomized controlled trial
  • electronic health record
  • oxidative stress
  • high resolution
  • contrast enhanced