Effect of Aspirin on Disability-free Survival in the Healthy Elderly.
John J McNeillRobyn L WoodsMark R NelsonChristopher M ReidBrenda KirpachRory WolfeElsdon StoreyRaj C ShahJessica E LockeryAndrew M TonkinAnne B NewmanJeff D WilliamsonKaren L MargolisMichael E ErnstWalter P AbhayaratnaNigel StocksSharyn M FitzgeraldSuzanne G OrchardRuth E TrevaksLawrence J BeilinGeoffrey A DonnanPeter GibbsColin I JohnstonJoanne RyanBarbara RadziszewskaRichard GrimmAnne M Murraynull nullPublished in: The New England journal of medicine (2018)
Aspirin use in healthy elderly persons did not prolong disability-free survival over a period of 5 years but led to a higher rate of major hemorrhage than placebo. (Funded by the National Institute on Aging and others; ASPREE ClinicalTrials.gov number, NCT01038583 .).