The Effect of Metformin on the Proliferation, Apoptosis and CD133 mRNA Expression of Colon Cancer Stem Cells by Upregulation of miR 342-3p.

Yaqin ZhangRuofei ChenLili DengZongwen ShuaiMingwei Chen

Published in: Drug design, development and therapy (2021)

MET upregulating the expression of miR-342-3p may not have a significant effect on the proliferation and apoptosis of CD133+ CCSCs, but it can reduce the expression of CD133 mRNA in CD133+ CCSCs.

Keyphrases

poor prognosis
stem cells
signaling pathway
oxidative stress
endoplasmic reticulum stress
nk cells
cell death
cell cycle arrest
binding protein
cell proliferation
long non coding rna
tyrosine kinase
mesenchymal stem cells
cell therapy