Pathological Roles of Pulmonary Cells in Acute Lung Injury: Lessons from Clinical Practice.
Noriyuki EnomotoPublished in: International journal of molecular sciences (2022)
Interstitial lung diseases (ILD) are relatively rare and sometimes become life threatening. In particular, rapidly progressive ILD, which frequently presents as acute lung injury (ALI) on lung histopathology, shows poor prognosis if proper and immediate treatments are not initiated. These devastating conditions include acute exacerbation of idiopathic pulmonary fibrosis (AE-IPF), clinically amyopathic dermatomyositis (CADM), epidermal growth factor receptor-tyrosine kinase inhibitor (EGFR-TKI)-induced lung injury, and severe acute respiratory syndrome coronavirus 2 (SARS-CoV2) infection named coronavirus disease 2019 (COVID-19). In this review, clinical information, physical findings, laboratory examinations, and findings on lung high-resolution computed tomography and lung histopathology are presented, focusing on majorly damaged cells in each disease. Furthermore, treatments that should be immediately initiated in clinical practice for each disease are illustrated to save patients with these diseases.
Keyphrases
- interstitial lung disease
- idiopathic pulmonary fibrosis
- coronavirus disease
- respiratory syndrome coronavirus
- epidermal growth factor receptor
- poor prognosis
- clinical practice
- tyrosine kinase
- sars cov
- systemic sclerosis
- induced apoptosis
- computed tomography
- advanced non small cell lung cancer
- high resolution
- cell cycle arrest
- long non coding rna
- rheumatoid arthritis
- lps induced
- lipopolysaccharide induced
- multiple sclerosis
- small cell lung cancer
- endoplasmic reticulum stress
- pulmonary hypertension
- liver failure
- respiratory failure
- physical activity
- positron emission tomography
- magnetic resonance imaging
- mental health
- intensive care unit
- healthcare
- systemic lupus erythematosus
- inflammatory response
- pi k akt
- mechanical ventilation
- cell proliferation
- pet ct