Sirtuin 5 Regulates Proximal Tubule Fatty Acid Oxidation to Protect against AKI.
Takuto ChibaKevin D PeasleyKasey R CargillKatherine V MaringerSivakama S BharathiElina MukherjeeYuxun ZhangAnja HoltzNathan BasistyShiva D YagobianBirgit SchillingEric S GoetzmanSunder Sims-LucasPublished in: Journal of the American Society of Nephrology : JASN (2019)
Our findings indicate that Sirt5 regulates the balance of mitochondrial versus peroxisomal fatty acid oxidation in proximal tubular epithelial cells to protect against injury in AKI. This novel mechanism might be leveraged for developing AKI therapies.