The Effects of High-Fat Diet and Flaxseed Oil-Enriched Diet on the Lung Parenchyma of Obese Mice.
Camila de Oliveira RamosMarcella Ramos Sant'AnaGiovana Rios GonçalvesThaiane da Silva RiosSusana Castelo Branco Ramos NakandakariBeatriz BurgerLuís Gustavo Romani FernandesRicardo de Lima ZollnerArthur Noin de OliveiraRodrigo Catharino RamosAdelino Sanchez Ramos da SilvaJosé Rodrigo PauliLeandro Pereira de MouraEduardo Rochete RopelleEli MansourDennys Esper Corrêa CintraPublished in: Molecular nutrition & food research (2024)
Omega-3 (ω3) fatty acids are widely investigated for their anti-inflammatory potential, however, there is little evidence regarding their action in the lung parenchyma in the context of obesity. The objective is to investigate the effects of flaxseed oil (FS), rich in α-linolenic (C18:3 - ω3), on the lungs of obese mice. Mice were fed a high-fat diet (HF) for 8 weeks to induce obesity. Subsequently, a part of these animals received HF containing FS oil for another 8 weeks. The HF consumption induced weight gain and hyperglycemia. The lung parenchyma shows a complete fatty acids profile, compared to the control group (CT). In the lung parenchyma, FS increases the ω3 content and, notwithstanding a reduction in the interleukins (IL) IL1β and IL18 contents compared to HF. However, FS promoted increased alveolar spaces, followed by MCP1 (Monocytes Chemoattractant Protein-1) positive cell infiltration and a dramatic reduction in the anti-inflammatory cytokine, IL10. Despite reducing the pulmonary inflammatory response, the consumption of a food source of ω3 was associated with alterations in the lipid profile and histoarchitecture of the lung parenchyma, which can lead to the development of pulmonary complications. This study brings an alert against the indiscriminate use of ω3 supplements, warranting caution.
Keyphrases
- high fat diet
- insulin resistance
- weight gain
- fatty acid
- adipose tissue
- high fat diet induced
- anti inflammatory
- weight loss
- inflammatory response
- metabolic syndrome
- pulmonary hypertension
- type diabetes
- body mass index
- acute heart failure
- computed tomography
- birth weight
- stem cells
- magnetic resonance imaging
- heart failure
- physical activity
- cell therapy
- dendritic cells
- atrial fibrillation
- lipopolysaccharide induced
- oxidative stress
- stress induced
- bone marrow
- image quality
- clinical decision support
- high resolution
- dual energy