HSPB7 oppositely regulates human mesenchymal stromal cell-derived osteogenesis and adipogenesis.

Shuang ZhangJeroen van de PeppelMarijke KoedamJohannes P T M van LeeuwenBram C J van der Eerden

Published in: Stem cell research & therapy (2023)

Our findings suggest that HSPB7 plays a positive role in driving osteoblastic differentiation, and with the capability in maintaining the osteo-adipogenesis balance. It holds great promise as a potential therapeutic target in the treatment of bone metabolic diseases.

Keyphrases

heat shock protein
bone marrow
endothelial cells
heat shock
stem cells
bone regeneration
high fat diet induced
vascular smooth muscle cells
induced pluripotent stem cells
soft tissue
combination therapy
pluripotent stem cells
bone loss
human health
angiotensin ii
heat stress
smoking cessation