Tumor Mutation Burden, Expressed Neoantigens and the Immune Microenvironment in Diffuse Gliomas.

Guangyang YuYing PangMythili Merchant Chimene A KesserwanVineela GangalapudiAbdalla AbdelmaksoudAlice Ranjan Olga Kim Jun S WeiHsien-Chao ChouXinyu WenSivasish SindiriYoung K SongLiqiang XiRosandra N KaplanTerri S ArmstrongMark R GilbertKenneth D Aldape Javed KhanJing Wu

Published in: Cancers (2021)

TMB was inversely correlated with immune score in IDH-wildtype gliomas and showed no correlation in IDH-mutant tumors. APP was correlated with immune score and may be further investigated as a biomarker for response to immunotherapy in gliomas. Studies of germline variants in a larger glioma cohort are warranted.

Keyphrases

high grade
low grade
wild type
stem cells
copy number
atomic force microscopy
high resolution
dna damage
genome wide