Viral Dynamics and Immune Correlates of Coronavirus Disease 2019 (COVID-19) Severity.

Barnaby E YoungSean Wei Xiang OngLisa F P NgDanielle E AndersonWan Ni ChiaPo Ying ChiaLi Wei AngTze-Minn MakShirin KalimuddinLouis Yi Ann ChaiSurinder PadaSeow Yen TanLouisa SunPurnima ParthasarathySiew-Wai FongYi-Hao ChanChee Wah TanBernett LeeOlaf RötzschkeYing DingPaul TambyahJenny G H LowLin CuiTimothy BarkhamRaymond Tzer Pin LinYee-Sin LeoLaurent ReniaLin-Fa WangDavid Chien Lyenull null

Published in: Clinical infectious diseases : an official publication of the Infectious Diseases Society of America (2021)

We found virus viability was associated with lower PCR Ct value in early illness. A stronger antibody response was associated with disease severity. The overactive proinflammatory immune signatures offer targets for host-directed immunotherapy, which should be evaluated in randomized controlled trials.

Keyphrases

coronavirus disease
sars cov
randomized controlled trial
respiratory syndrome coronavirus
computed tomography
image quality
dual energy
contrast enhanced
magnetic resonance imaging
genome wide
clinical trial
systematic review
magnetic resonance
dna methylation
double blind