Engineered Exosomes Containing microRNA-29b-2 and Targeting the Somatostatin Receptor Reduce Presenilin 1 Expression and Decrease the β-Amyloid Accumulation in the Brains of Mice with Alzheimer's Disease.
En-Yi LinShao-Xi HsuBing-Hua WuYu-Chen DengWei WuliYuan-Sheng LiJui-Hao LeeShinn-Zong LinHorng-Jyh HarnTzyy-Wen ChiouPublished in: International journal of nanomedicine (2024)
Our results demonstrated the feasibility of the designed engineered exosomes. The application of this exosomal nanocarrier platform can be extended to the delivery of other oligonucleotide drugs to specific tissues for the treatment of diseases while evading the immune system.