Angiotensin-(1-7) Analogue AVE0991 Modulates Astrocyte-Mediated Neuroinflammation via lncRNA SNHG14/miR-223-3p/NLRP3 Pathway and Offers Neuroprotection in a Transgenic Mouse Model of Alzheimer's Disease.
Rui DuanSi-Yu WangBin WeiYang DengXin-Xin FuPeng-Yu GongYan EXiao-Jin SunHai-Ming CaoJian-Quan ShiTeng JiangYing-Dong ZhangPublished in: Journal of inflammation research (2021)
Our results suggest that Ang-(1-7) analogue AVE0991 inhibits astrocyte-mediated neuroinflammation via SNHG14/miR-223-3p/NLRP3 pathway and offers neuroprotection in APP/PS1 mice. These findings reveal the underlying mechanisms by which Ang-(1-7) inhibits neuroinflammation under AD condition and uncover the potential of its nonpeptide analogue AVE0991 in AD treatment.
Keyphrases
- cerebral ischemia
- angiotensin ii
- lipopolysaccharide induced
- lps induced
- mouse model
- traumatic brain injury
- subarachnoid hemorrhage
- brain injury
- cognitive impairment
- poor prognosis
- blood brain barrier
- inflammatory response
- angiotensin converting enzyme
- long non coding rna
- nlrp inflammasome
- genome wide
- cognitive decline
- type diabetes
- high fat diet induced
- gene expression
- risk assessment
- adipose tissue
- dna methylation
- skeletal muscle
- human health
- insulin resistance
- long noncoding rna