Growth differentiation factor-15 as a biomarker of strength and recovery in survivors of acute respiratory failure.
Brian J RosenbergMichio HiranoCatarina M QuinziiElizabeth ColantuoniDale M NeedhamDavid J LedererMatthew R BaldwinPublished in: Thorax (2019)
Muscle mitochondrial dysfunction is implicated in intensive care unit-acquired weakness, but there is no serum biomarker of muscle mitochondrial function for critical illness survivors. Higher serum growth differentiation factor-15 (GDF-15) is a biomarker of inherited mitochondrial myopathy disease and is associated with mortality in several age-related diseases. Among 142 older (age ≥ 65 years) survivors of acute respiratory failure, we found that higher serum GDF-15 measured during the week prior to hospital discharge was cross-sectionally associated with weaker diaphragm, limb and hand-grip strength, and longitudinally associated with lower rates of functional recovery over 6 months, independent of age, sex, pre-existing disability, comorbidity, frailty, Acute Physiology and Chronic Health Evaluation II scores and concurrent interleukin-6 levels.
Keyphrases
- respiratory failure
- mechanical ventilation
- intensive care unit
- extracorporeal membrane oxygenation
- acute respiratory distress syndrome
- young adults
- skeletal muscle
- public health
- healthcare
- multiple sclerosis
- mental health
- oxidative stress
- type diabetes
- clinical trial
- squamous cell carcinoma
- late onset
- randomized controlled trial
- coronary artery disease
- cardiovascular events
- risk factors
- early onset
- health information
- locally advanced
- study protocol
- myasthenia gravis