Hyperglucagonemia in youth is associated with high plasma free fatty acids, visceral adiposity, and impaired glucose tolerance.
Hannes ManellHjalti KristinssonJoel KullbergSarojini Jayantha Kumari UbhayasekeraKatharina MörwaldJohan StaafJanne CadamuroFanni ZsoldosSven GöpelErnest SargsyanHåkan AhlströmJonas BergquistDaniel WeghuberAnders ForslundPeter BergstenPublished in: Pediatric diabetes (2019)
Hyperglucagonemia in childhood obesity is associated with hyperinsulinemia, high plasma FFAs, high plasma triglycerides, visceral adiposity, and IGT. The glucagonotropic effect of FFAs on isolated human islets provides a potential mechanism linking high fasting plasma FFAs and glucagon levels.