Primary cancer-associated fibroblasts exhibit high heterogeneity among breast cancer subtypes.

Oliwia PiwockaMarika MusielakIgor PiotrowskiKatarzyna KulcentyBeata AdamczykMagdalena FundowiczWiktoria Maria SuchorskaJulian Malicki

Published in: Reports of practical oncology and radiotherapy : journal of Greatpoland Cancer Center in Poznan and Polish Society of Radiation Oncology (2023)

According to our findings, there was no significant pattern in the classification of cancer-associated fibroblasts. The results of biomarkers expression were heterogeneous, thus no specific subtypes were identified. Furthermore, a comparison of cancer-associated fibroblasts derived from different BC subtypes (luminal A and B, triple-negative, HER2 positive) did not reveal any clear trend of expression.

Keyphrases

poor prognosis
extracellular matrix
single cell
machine learning
binding protein
long non coding rna
genome wide
gene expression
young adults