ADAMTS13 inhibits oxidative stress and ameliorates progressive chronic kidney disease following ischaemia/reperfusion injury.
Suhan ZhouJie GuoLiang ZhaoYixin LiaoQin ZhouYu CuiWeipeng HuJianghua ChenXiaoqiu RenQichun WeiShan JiangYali ZhengLingli LiChristopher S WilcoxPontus B PerssonAndreas PatzakJiong TianEn-Yin LaiPublished in: Acta physiologica (Oxford, England) (2020)
Acute kidney injury (AKI) reduces the expression of ADAMTS13 that contributes to progressive CKD, microvascular dysfunction, oxidative stress, inhibition of Nrf2 activity and renal histopathological damage. All of which can be alleviated by administration of rhADAMTS13.
Keyphrases
- oxidative stress
- acute kidney injury
- chronic kidney disease
- multiple sclerosis
- end stage renal disease
- cardiac surgery
- diabetic rats
- dna damage
- induced apoptosis
- ischemia reperfusion injury
- poor prognosis
- acute myocardial infarction
- mouse model
- cerebral ischemia
- binding protein
- heart failure
- long non coding rna
- blood brain barrier
- acute coronary syndrome
- left ventricular
- heat shock
- atrial fibrillation
- percutaneous coronary intervention
- coronary artery disease