Allosteric inhibition of CRISPR-Cas9 by bacteriophage-derived peptides.

Yan-Ru CuiShao-Jie WangJun ChenJie LiWenzhang ChenShuyue WangBing MengWei ZhuZhuhong ZhangBei YangBiao JiangGuang YangPeixiang Ma Jia Liu

Published in: Genome biology (2020)

G8Ps discovered in the current study represent the first anti-CRISPR peptides that can allosterically inactivate CRISPR-Cas9. This finding may provide insights into developing next-generation CRISPR-Cas inhibitors for precision genome engineering.

Keyphrases

crispr cas
genome editing
small molecule
amino acid
gene expression