Porcine signal regulatory protein alpha binds to human CD47 to inhibit phagocytosis: Implications for human hematopoietic stem cell transplantation into severe combined immunodeficient pigs.

Adeline N BoettcherJoan E CunnickEllie J PutzTimothy K EgnerSara E CharleyCrystal L Loving Christopher K Tuggle

Published in: Xenotransplantation (2018)

We have shown the first evidence that porcine monocytes can bind to human CD47 and are phagocytically tolerant to human cells, suggesting that porcine SCID models have the potential to support engraftment of human HSCs.

Keyphrases

endothelial cells
induced pluripotent stem cells
pluripotent stem cells
immune response
small molecule
early onset
peripheral blood
climate change
binding protein
cord blood