A designed cyclic analogue of gomesin has potent activity against Staphylococcus aureus biofilms.
Susana A DiasSandra N PintoAna S Silva-HerdadeOlivier ChenevalDavid J CraikAna CoutinhoMiguel A R B CastanhoSónia T HenriquesAna Salomé VeigaPublished in: The Journal of antimicrobial chemotherapy (2022)
The results suggest that the 3D structure of [G1K,K8R]cGm and its stabilization by disulphide bonds are essential for its antibacterial and antibiofilm activities. Moreover, our findings support the potential application of this stable cyclic antimicrobial peptide to fight bacterial biofilms.