The Effect and Mechanism of KLF7 in the TLR4/NF-κB/IL-6 Inflammatory Signal Pathway of Adipocytes.

Meixiu ZhangCuizhe WangJinxiu WuXiaodan HaYuchun DengXueting ZhangJingzhou WangKeru ChenJiale FengJiaojiao ZhuJianxin Xie Jun Zhang

Published in: Mediators of inflammation (2018)

PA promotes the expression of the inflammatory cytokine IL-6 by activating the TLR4/KLF7/NF-κB inflammatory signaling pathway. In addition, KLF7 may directly bind to the IL-6 promoter region and thus activate IL-6.

Keyphrases

signaling pathway
oxidative stress
pi k akt
transcription factor
nuclear factor
inflammatory response
toll like receptor
immune response
lps induced
epithelial mesenchymal transition
adipose tissue
poor prognosis
gene expression
type diabetes
cell proliferation
metabolic syndrome
insulin resistance
binding protein