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Rejuvenating the Activity of Usual Antibiotics on Resistant Gram-Negative Bacteria: Recent Issues and Perspectives.

Jinane TabchehJulia VergalliAnne Davin-RégliNoha GhanemJean Marie PagèsCharbel Al-BayssariJean-Michel Brunel
Published in: International journal of molecular sciences (2023)
Antibiotic resistance continues to evolve and spread beyond all boundaries, resulting in an increase in morbidity and mortality for non-curable infectious diseases. Due to the failure of conventional antimicrobial therapy and the lack of introduction of a novel class of antibiotics, novel strategies have recently emerged to combat these multidrug-resistant infectious microorganisms. In this review, we highlight the development of effective antibiotic combinations and of antibiotics with non-antibiotic activity-enhancing compounds to address the widespread emergence of antibiotic-resistant strains.
Keyphrases
  • infectious diseases
  • multidrug resistant
  • escherichia coli
  • staphylococcus aureus
  • drug resistant
  • gram negative
  • mesenchymal stem cells