A Two-way Randomized Cross-over Pharmacokinetic and Pharmacodynamic Study of an Innovative Oral Solution of Midazolam (ADV6209).

Catherine GuittetMaria MansoIngrid BurtonLuc-André GranierFrédéric Marçon

Published in: Pharmaceutical research (2017)

Cyclodextrins have little impact on midazolam oral bioavailability and the pharmacokinetics parameters of midazolam formulation ADV6209 are close to those reported previously.

Keyphrases

double blind
open label
drug delivery
randomized controlled trial
phase ii
mass spectrometry
solid state