Acute normobaric hypoxia blunts contraction-mediated mTORC1- and JNK-signaling in human skeletal muscle.
Marcus MobergWilliam ApróOscar HorwathGerrit van HallSarah Joan BlackwoodAbram KatzPublished in: Acta physiologica (Oxford, England) (2022)
We conclude that acute severe hypoxia inhibits resistance exercise-induced mTORC1- and JNK signalling in human skeletal muscle, effects that do not appear to be mediated by changes in the degree of metabolic stress in the muscle.
Keyphrases
- skeletal muscle
- endothelial cells
- liver failure
- insulin resistance
- signaling pathway
- drug induced
- respiratory failure
- induced pluripotent stem cells
- cell death
- pluripotent stem cells
- induced apoptosis
- hepatitis b virus
- oxidative stress
- smooth muscle
- heat stress
- extracorporeal membrane oxygenation
- intensive care unit
- endoplasmic reticulum stress