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Huperzine A suppresses absence seizures in the genetic absence epilepsy rat from Strasbourg (GAERS) model of genetic generalized epilepsy with absence seizures.

Pablo Miguel Casillas-EspinosaJennie Garcia-OlivaresRui LiCrystal LiChungping YuAndrea E FormellaTerence J O'Brien
Published in: Epilepsia open (2024)
This study looked at how huperzine A affects seizures in rats with similar abnormal brain activity as seen in humans with absence epilepsy. Rats received different treatments, placebo (i.e., saline solution), huperzine A, and ethosuximide. Ethosuximide is considered a gold standard treatment for absence epilepsy. We recorded brain activity to measure seizures before and after each treatment. We found that huperzine A (3.0 mg/kg) reduced seizures soon after treatment, like ethosuximide. Both treatments appeared safe, causing only mild sleepiness. The study shows that huperzine A could be a good new treatment for a type of absence epilepsy.
Keyphrases
  • temporal lobe epilepsy
  • randomized controlled trial
  • oxidative stress
  • genome wide
  • signaling pathway
  • gene expression
  • dna methylation
  • copy number
  • sleep apnea