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CD8+ and Regulatory T cells Differentiate Tumor Immune Phenotypes and Predict Survival in Locally Advanced Head and Neck Cancer.

Alessia EchartiMarkus HechtFrederick PfisterMarlen HaderleinArndt HartmannRainer FietkauLuitpold Distel
Published in: Cancers (2019)
We propose that, in locally advanced HNSCC, the tumor immune state "inflamed", "immune excluded", and "immune desert" can be defined by intraepithelial and stromal CTL. Tregs can further subdivide these groups. The opposing effects of Tregs in the different groups might be the reason for the inconsistency of Tregs prognostic values published earlier.
Keyphrases
  • locally advanced
  • regulatory t cells
  • squamous cell carcinoma
  • rectal cancer
  • neoadjuvant chemotherapy
  • radiation therapy
  • high grade
  • randomized controlled trial
  • immune response
  • lymph node
  • free survival