High Mobility Group Box 1/Toll-like Receptor 4 Signaling Increases GABRB3 Expression in Alcohol Exposure.

Guangtao SunXunzhong QiWei WangXintong LiChunhua LuoShunjie BaiShaohua XuXiaogang ZhongChenglong HuangXiaofeng ZhuZuoyi Huang

Published in: Neuropsychiatric disease and treatment (2021)

Through the reanalysis of GSE123114 microarray profile, we found that Gabrb3 is a key gene associated with alcohol exposure. In further experiments, our findings suggest that alcohol exposure modulates Gabrb3 expression through the HMGB1/TLR4 pathway. Moreover, inflammation-associated factors, such as IL-1β and TNFα, may be related to the HMGB1/TLR4-mediated regulation of GABRB3 expression in alcohol exposure.

Keyphrases

toll like receptor
poor prognosis
inflammatory response
nuclear factor
immune response
binding protein
oxidative stress
rheumatoid arthritis
transcription factor
gene expression
copy number
drug induced