Ru(II)-Catalyzed C-H Functionalization of N-Hydroxyoximes with 1,3-Diynes Unveils a Regioselective Disparity.

Shreemoyee Kumar Akshay M Nair Chandra M R Volla

Published in: Organic letters (2020)

A highly selective and convenient Ru(II)-catalyzed C-H bond activation protocol has been demonstrated to access 4-alkynylated isoquinolines, which was so far elusive from 1,3-diynes. Subsequently, the same protocol was extended to furnish various 4-4'-biisoquinoline motifs. The key feature of this work is the regioselective disparity observed during the migratory insertion of an organoruthenium metallacycle with the C3-C4 triple bond of 1,3-diynes resulting in divergent products as compared to the existing literature.

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