The bipolar depression electrical treatment trial (BETTER): design, rationale, and objectives of a randomized, sham-controlled trial and data from the pilot study phase.

Bernardo de Sampaio Pereira JuniorGabriel Tortella Beny LaferPaula NunesIsabela Martins BenseñorPaulo Andrade LotufoRodrigo Machado-VieiraAndré R Brunoni

Published in: Neural plasticity (2015)

This upcoming clinical trial will address the efficacy of tDCS for BD on different degrees of refractoriness. The evaluation of biological markers will also help in understanding the pathophysiology of BD and the mechanisms of action of tDCS.

Keyphrases

clinical trial
double blind
study protocol
transcranial direct current stimulation
phase ii
phase iii
open label
depressive symptoms
randomized controlled trial
bipolar disorder
electronic health record
big data
combination therapy
artificial intelligence
data analysis