A structural perspective on the temperature-dependent activity of enzymes.
Matthew J McLeodSarah A E BarwellTodd HolyoakRobert Edward ThornePublished in: bioRxiv : the preprint server for biology (2024)
Structural data spanning a 60°C temperature range for enzyme complexes mimicking the substrate-, intermediate-, and product-bound states illuminate how small temperature-dependent structural changes may modulate activity and render parameters deduced from Arrhenius/Eyring plots unreliable.
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