Thyroid hormone and folinic acid in young children with Down syndrome: the phase 3 ACTHYF trial.
Clotilde MircherSilvia SaccoCharles BouisJennifer GallardAude PichotEric Le GalloudecCécile CieutaIsabelle MareyOliver Greiner-MahlerNathalie DorisonAlicia GambariniSamantha StoraSophie DurandMichel PolakAndré BaruchelEmilie SchlumbergerJean DewaillyAhlam Azar-KolakezRosa-Maria Guéant-RodriguezJean-Louis GuéantDidier BorderieDominique Bonnefont-RousselotElodie BlondiauxAimé RavelFranck G SturtzPublished in: Genetics in medicine : official journal of the American College of Medical Genetics (2019)
This trial does not support the hypotheses that thyroxine and/or folinic acid improve development of young children with DS or are synergistic. This trial is registered with ClinicalTrials.gov number, NCT01576705.