Accurate genome-wide genotyping from archival tissue to explore the contribution of common genetic variants to pre-cancer outcomes.
Daniela NachmansonMeghana PagadalaJoseph StewardCallie CheungLauryn Keeler BruceNicole Q LeeThomas J O'KeefeGrace Y LinFarnaz HastehGerald P MorrisHannah CarterOlivier HarismendyPublished in: Journal of translational medicine (2022)
Archival tissue DNA germline profiling using lc-WGS and imputation, represents a cost and resource-effective alternative in the retrospective design of long-term disease genetic studies. Initial results in breast cancer suggest that common risk variants contribute to pre-cancer progression.