Genetic analysis of cervical cancer with lymph node metastasis.
Hao HeMisi HeQi ZhouYing TangJing WangXiuying LiDongling ZouPublished in: Journal of gynecologic oncology (2024)
The somatic SNV/Indels of EP300 and FBXW7, SBS3 homologous recombination-mediated DNA repair defect were enriched in lymph node-positive patients. For lymph node-positive patients, EP300 or FBXW7 mutations predicted poor prognosis. No matter lymph node-positive or negative, more co-occurring mutation number predicted poor prognosis. PIK3CA mutation may account for the higher TMB and help identify patients who benefit from immunotherapy.
Keyphrases
- poor prognosis
- lymph node
- dna repair
- end stage renal disease
- long non coding rna
- lymph node metastasis
- dna damage
- newly diagnosed
- ejection fraction
- chronic kidney disease
- squamous cell carcinoma
- prognostic factors
- neoadjuvant chemotherapy
- peritoneal dialysis
- oxidative stress
- gene expression
- dna damage response
- radiation therapy
- rectal cancer
- locally advanced