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H3K27M-mutant glioma in thoracic spinal cord and conus medullaris with pilocytic astrocytoma morphology: case report and review of the literature.

Alexis J Palpán-FloresVíctor Rodríguez DomínguezIsabel Esteban RodriguezMaría Román de AragónÁlvaro Zamarrón Pérez
Published in: British journal of neurosurgery (2021)
The H3K27M-mutant spinal cord glioma is a very infrequent tumor with a wide variety of histological presentations even as indolent as pilocytic astrocytoma, which should be considered in spinal cord tumors, especially if there are clinical, histological, or radiological data that suggest aggressiveness. On the other hand, the fast progression led to the loss of complete neurological function distal to the tumor, in spinal tumors could explain a not so poor prognosis as it is in functionally and vital structures.
Keyphrases
  • spinal cord
  • poor prognosis
  • neuropathic pain
  • spinal cord injury
  • long non coding rna
  • wild type
  • high resolution
  • machine learning
  • minimally invasive
  • deep learning
  • data analysis
  • cerebral ischemia